![]() ![]() Methods: The goodness of fit and discriminatory accuracy of the models was assessed using data from 1933 women attending the Family History Evaluation and Screening Programme, of whom 52 developed cancer. Therefore, this study has assessed the goodness of fit and discriminatory value of the Tyrer–Cuzick model against established models namely Gail, Claus, and Ford. A new model by Tyrer and Cuzick has addressed these deficiencies. However, no single model integrates family history, hormonal factors, and benign breast disease in a comprehensive fashion. Several mathematical models for the estimation of individual breast cancer risk have been proposed. Introduction: Accurate individualised breast cancer risk assessment is essential to provide risk–benefit analysis prior to initiating interventions designed to lower breast cancer risk. ![]()
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